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EB Publications

The following publications are partly based on test results obtained in studies performed by Emotional Brain.

The results of the various experiments described in these articles show that the conclusion is justified that there are, indeed, differences in the way sexual stimuli are processed in the brains of individual women. Furthermore, these differences seem to originate from different causes. Whereas in one subgroup, relative insensitivity to sexual stimuli seems congenital, the sexual inhibition in the other subgroup seems to be caused by a combination of brain-related factors and the subject’s sexual history.
 

EB Publications

Year 2016

Bloemers J, van Rooij K, de Leede L, Frijlink HW, Koppeschaar HPF, Olivier B, Tuiten A. Single dose sublingual testosterone and oral sildenafil versus a dual-route/dual-release fixed-dose combination tablet: a pharmacokinetic comparison. BJ Clin Pharm 2016. DOI: 10.1111/bcp.12887 [Epub ahead of print]

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Year 2015

Suschinsky KD, Shelley AJ, Gerritsen J, Tuiten A, Chivers ML. The Clitoral Photoplethysmograph: A Pilot Study Examining Discriminant and Convergent Validity. Sex Med. 2015 Dec;12(12):2324-38

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van Rooij K. Treatment of female sexual dysfunction: a personalized medicine approach. PhD thesis, 2015. ISBN 978-94-6108-912-0

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Year 2014

Bloemers J. Sex, Drugs & Dual Control. A personalized sexual medicine drug development program based on the dual control model of sexual response. PhD thesis, 2014. ISBN 978-90-5335-894-8 

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van Rooij K, Poels S, Worst P, Bloemers J, Koppeschaar H, Goldstein A, Olivier B, Tuiten A. Efficacy of testosterone combined with a PDE5 inhibitor and testosterone combined with a serotonin 1A receptor agonist in women with SSRI-induced sexual dysfunction. Eur J Pharmacol, 2014. In print.

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Tuiten A, Bloemers J, van Rooij K, Poels S, Gerritsen J, van Ham D, de Leede L, Everard W. Response to “Towards Personalized Medicine: Where is the Evidence?”. J Sex Med, 2014;11:2359-2363.

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van Rooij K, de Leede L, Frijlink H, Bloemers J, Poels S, Koppeschaar H, Olivier B, Tuiten A. Pharmacokinetics of a prototype formulation of sublingual testosterone and a buspirone tablet, versus an advanced combination tablet of testosterone and buspirone in healthy premenopausal women. Drugs in R&D, 2014;14:125-32.

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Poels S, Bloemers J, van Rooij K, Koppeschaar H, Olivier B, Tuiten A. Two novel combined drug treatments for women with Hypoactive Sexual Desire Disorder. Pharmacology, Biochemistry and Behavior, 2014;121:71-79.

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Poels S, Bloemers J, van Rooij K, Koppeschaar H, Olivier B, Tuiten A. Een vernieuwende farmacotherapeutische behandeling voor vrouwen met Hypoactive Sexual Desire Disorder [A new pharmacotherapeutic treatment for women with Hypoactive Sexual Desire Disorder]. Neuropraxis, 2014;18(1):32-45

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Bloemers J, Scholte HS, van Rooij K, Goldstein I, Gerritsen J, Olivier B, Tuiten A. Reduced Gray Matter Volume and Increased White Matter Fractional Anisotropy in Women with Hypoactive Sexual Desire Disorder. J Sex Med, 2014;11:753–767

http://onlinelibrary.wiley.com/doi/10.1111/jsm.12410/abstract

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Year 2013

Bloemers J, van Rooij K, Poels S, Goldstein I, Everaerd W, Koppeschaar H, Chivers M, Gerritsen J, van Ham D, Olivier B, Tuiten A.Toward Personalized Sexual Medicine (Part 1): Integrating the “Dual Control Model” into Differential Drug Treatments for HSDD and FSAD. Journal of Sexual Medicine 2013;10 (3):791-809.

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Poels S, Bloemers J, van Rooij K, Goldstein I, Gerritsen J, van Ham D, van Mameren F, Chivers M, Everaerd W, Koppeschaar H, Olivier B, Tuiten A. Toward Personalized Sexual Medicine (Part 2): Testosterone combined with a PDE5 inhibitor increases sexual satisfaction in women with HSDD and FSAD, and a low sensitive system for sexual cues. Journal of Sexual Medicine 2013;10 (3):810-823.

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van Rooij K, Poels S, Bloemers J, Goldstein I, Gerritsen J, van Ham D, van Mameren F, Chivers M, Everaerd W, Koppeschaar H, Olivier B, Tuiten A. Toward Personalized Sexual Medicine (Part 3): Testosterone combined with a serotonin1A receptor agonist increases  sexual satisfaction in women with HSDD and FSAD, and dysfunctional activation of sexual inhibitory mechanisms. Journal of Sexual Medicine 2013;10 (3):824-837.

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Year 2012

van Rooij K, Bloemers J, de Leede L, Goldstein I, Lentjes E, Koppeschaar H, Olivier B, Tuiten A. Pharmacokinetics of three doses of sublingual testosterone in healthy premenopausal women. Psychoneuroendocrinology 2012;37(6):773-81.
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Year 2010

Bloemers J, Gerritsen J, Bults R, Koppeschaar H, Everaerd W, Olivier B, Tuiten A. Induction of sexual arousal in women under conditions of institutional and ambulatory laboratory circumstances: a comparative study. Journal of Sexual Medicine 2010; 7(3):1160-76

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Year 2009

Gerritsen J, van der Made F, Bloemers J, van Ham D, Kleiverda G, Everaerd W, Olivier B, Levin R, Tuiten A. The clitoral photoplethysmograph: a new way of assessing genital arousal in women. Journal of Sexual Medicine 2009;6(6):1678-87
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van der Made F, Bloemers J, van Ham D, El Yassem W, Kleiverda G, Everaerd W, Olivier B, Tuiten A. Childhood sexual abuse, selective attention for sexual cues and the effects of testosterone with or without vardenafil on physiological sexual arousal in women with sexual dysfunction: a pilot study. Journal of Sexual Medicine 2009;6(2):429-39
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van der Made F, Bloemers J, Yassem WE, Kleiverda G, Everaerd W, van Ham D, Olivier B, Koppeschaar H, Tuiten A. The influence of testosterone combined with a PDE5-inhibitor on cognitive, affective, and physiological sexual functioning in women suffering from sexual dysfunction. Journal of Sexual Medicine 2009;6(3):777-90
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Year 2002

Tuiten A, van Honk J, Verbaten R, Laan E, Everaerd W, Stam H. Can sublingual testosterone increase subjective and physiological measures of laboratory-induced sexual arousal? Archives of General Psychiatry, 2002; 59:465–466.
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Year 2000

Tuiten A, van Honk J, Koppeschaar H, Bernaards C, Thijssen J, Verbaten R. Time course of effects of testosterone administration on sexual arousal in women. Archives of General Psychiatry 2000;57(2):149-53

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